Deep Learning-Based Image Analysis for Glaucoma Diagnosis

Main Article Content

Kanyanee Nameam
Parinya Natho

Abstract

This research aims to develop a Convolutional Neural Network (CNN) model for the automatic classification of glaucoma from retinal fundus images. The dataset consisted of 1,000 eye images, divided into normal and glaucoma groups, collected from online databases and patients at Rajthanee Hospital, Rojana, Phra Nakhon Si Ayutthaya Province.The proposed model is a 5-layer CNN architecture designed to suit color image data. The data preprocessing steps included image resizing, grayscale conversion, and data augmentation to increase the diversity of the training dataset. Model performance was evaluated using 5-fold cross-validation on a training and validation set of 800 images. The results showed that the model achieved an accuracy of 87% during training. When tested with a new dataset of 200 images, the model demonstrated high performance, achieving an accuracy of 94.0%, precision of 93.1%, recall of 95.0%, F1-score of 94.0%, and an AUC of 0.98. These results indicate the model’s strong accuracy and balance in distinguishing between normal and glaucoma images, suggesting that the developed CNN model can be effectively applied in real-world scenarios, particularly in healthcare facilities with limited resources and specialized personnel.

Article Details

How to Cite
Nameam, K., & Natho, P. (2026). Deep Learning-Based Image Analysis for Glaucoma Diagnosis. The Golden Teak : Science and Technology Journal (GTSJ.), 12(2), 75–98. retrieved from https://li02.tci-thaijo.org/index.php/gts/article/view/2009
Section
Research Article

References

จิราภรณ์ บุญประเสริฐ. (2564). ปัจจัยเสี่ยงของโรคต้อหินในประชากรไทย. วารสารวิจัยสุขภาพ, 25(3), 100-110.

ทรงกรด พิมพิศาล, และณัฐวุฒิ ศรีวิบูลย์. (2563). การจำแนกระดับความรุนแรงของโรคเบาหวานขึ้นจอประสาทตาด้วยโครงข่ายประสาทเทียมแบบคอนโวลูชัน. วารสารวิชาการเทคโนโลยีและสถิติ, 13(1), 15-26. https://doi.org/10.14456/jist.2020.14

ศิริพร วงศ์คำ. (2565). การศึกษาการพบโรคต้อหินในผู้ป่วยหลังผ่าตัดต้อกระจกที่โรงพยาบาลเชียงรายประชานุเคราะห์. โรงพยาบาลเชียงรายประชานุเคราะห์.

สำนักโรคตา. (2563). รายงานสถานการณ์โรคต้อหินในประเทศไทย. สำนักโรคตา กรุงเทพมหานคร.

Ahmed, M., Rahman, S., and Chowdhury, A. (2025). OcuMDNet: A lightweight CNN for robust multi-disease classification using fundus images. Experimental Eye Research, 242, 110278. https://doi.org/10.1016/j.exer.2025.110278

Ehrlich, J. R., Lee, D. J., Friedman, D. S., Boland, M. V., Ramulu, P. Y., and Swenor, B. K. (2024). Prevalence of glaucoma among US adults in 2022. JAMA Ophthalmology, 142(11), 1046-1053. https://doi.org/10.1001/jamaophthalmol.2024.3884

Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., and Thrun, S. (2017). Dermatologist-level classification of skin cancer with deep neural networks. Nature, 542(7639), 115-118. https://doi.org/10.1038/nature21056

George, R., Ve, R. S., Baskaran, M., Ramesh, S. V., Raju, P., Arvind, H., and Vijaya, L. (2003). The Chennai Glaucoma Study: Prevalence of glaucoma in a rural population. Investigative Ophthalmology & Visual Science, 44(10), 4262-4269. https://doi.org/10.1167/iovs.03-0274

Gulshan, V., Peng, L., Coram, M., Stumpe, M. C., Wu, D., Narayanaswamy, A., Venugopalan, S., Widner, K., Madams, T., Cuadros, J., Kim, R., Raman, R., Nelson, P. C., Mega, J. L., and Webster, D. R. (2016). Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA, 316(22), 2402-2410. https://doi.org/10.1001/jama.2016.17216

Howard, A. G., Zhu, M., Chen, B., Kalenichenko, D., Wang, W., Weyand, T., Andreetto, M., and Adam, H. (2017). MobileNets: Efficient convolutional neural networks for mobile vision applications. arXiv:1704.04861.

Jammal, A. A., Thompson, A. C., Mariottoni, E. B., Berchuck, S. I., and Medeiros, F. A. (2021). Human–machine collaboration for glaucoma detection and visual field prediction. Ophthalmology, 128(11), 1572-1574. https://doi.org/10.1016/j.ophtha.2021.05.002

Jonas, J. B., Aung, T., Bourne, R. R. A., Bron, A. M., Ritch, R., and Panda-Jonas, S. (2017). Glaucoma. The Lancet, 390(10108), 2183-2193. https://doi.org/10.1016/S0140-6736(17)31469-1

Kurmann, T., Antoniadis, I., Wong, T. Y., and Webb, A., (2020). In-depth evaluation of saliency maps for interpreting convolutional neural network decisions in the diagnosis of glaucoma based on fundus imaging. Investigative Ophthalmology & Visual Science, 61(7), 2381-2392. https://doi.org/10.1167/iovs.61.7.2381

Li, Z., He, Y., Keel, S., Meng, W., Chang, R. T., and He, M. (2018). Efficacy of a deep learning system for detecting glaucomatous optic neuropathy based on color fundus photographs. Ophthalmology, 125(8), 1199-1206. https://doi.org/10.1016/j.ophtha.2018.01.023

Li, Z., He, Y., Keel, S., Meng, W., Chang, R. T., and He, M. (2020). A comparative study of RGB and grayscale fundus images in glaucoma detection using deep learning. BMC Ophthalmology, 20(1), 245. https://bmcophthalmol.biomedcentral.com/

Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., van Ginneken, B., and Sánchez, C. I. (2017). A survey on deep learning in medical image analysis. Medical Image Analysis, 42, 60-88. https://doi.org/10.1016/j.media.2017.07.005

Lundervold, A. S., and Lundervold, A. (2019). An overview of deep learning in medical imaging focusing on MRI. Zeitschrift für Medizinische Physik, 29(2), 102-127. https://doi.org/ 10.1016/j.zemedi.2018.11.002

Medeiros, F. A., and Jammal, A. A. (2022). Artificial intelligence and teleophthalmology: Opportunities and challenges for glaucoma care. Current Opinion in Ophthalmology, 33(2), 93-99. https://doi.org/10.1097/ICU.0000000000000822

Oakden-Rayner, L. (2021). Exploring data leakage in medical imaging datasets. PMC.

Prabhakar, K., Sharma, N., and Gupta, R. (2024). A lightweight CNN for multiclass retinal disease detection under constrained environments. BMC Ophthalmology, 24(2), 310. https://pmc.ncbi.nlm.nih.gov/articles/PMC12387214/

Quigley, H. A., and Broman, A. T. (2006). The number of people with glaucoma worldwide in 2010 and 2020. British Journal of Ophthalmology, 90(3), 262-267. https://doi.org/ 10.1136/bjo.2005.081224

Ravi, D., Wong, C., Deligianni, F., Berthelot, M., Andreu-Perez, J., Lo, B., and Yang, G. Z. (2017). Deep learning for health informatics. IEEE Journal of Biomedical and Health Informatics, 21(1), 4-21. https://doi.org/10.1109/JBHI.2016.2636665

Saito, T., and Rehmsmeier, M. (2015). The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets. PLOS ONE, 10(3), e0118432. https://doi.org/10.1371/journal.pone.0118432

Sandler, M., Howard, A., Zhu, M., Zhmoginov, A., and Chen, L. C. (2018). MobileNetV2: Inverted residuals and linear bottlenecks. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 4510-4520.

Shibata, N., Tanito, M., Mitsuhashi, K., Fujino, Y., Matsuura, M., Murata, H., and Asaoka, R. (2018). Development of a deep residual learning algorithm to screen for glaucoma from fundus photography. Scientific Reports, 8, 14665. https://doi.org/10.1038/s41598-018-33013-w

Shin, H.-C., Roth, H. R., Gao, M., Lu, L., Xu, Z., Nogues, I., Yao, J., Mollura, D., and Summers, R. M. (2016). Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Transactions on Medical Imaging, 35(5), 1285-1298. https://doi.org/10.1109/ TMI.2016.2528162

Shorten, C., and Khoshgoftaar, T. M. (2019). A survey on image data augmentation for deep learning. Journal of Big Data, 6(1), 1-48. https://doi.org/10.1186/s40537-019-0197-0

Tham, Y. C., Li, X., Wong, T. Y., Quigley, H. A., Aung, T., and Cheng, C. Y. (2014). Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology, 121(11), 2081-2090. https://doi.org/10.1016/j.ophtha.2014.05.013

Thongthong, A. (2021). Prevalence of glaucomatous blindness. Eye South East Asia, 16(2), 69–77. https://he01.tci-thaijo.org/index.php/eyesea/ article/view/248101/171515

Vijaya, L., George, R., Baskaran, M., Arvind, H., Raju, P., Ramesh, S. V., Kumaramanickavel, G., and McCarty, C. (2008). Prevalence of primary open-angle glaucoma in an urban south Indian population and comparison with a rural population: The Chennai Glaucoma Study. Ophthalmology, 115(4), 648-654. https://doi.org/10.1016/j.ophtha.2007.04.062

Zhang, X., Li, Y., and Wong, T. Y. (2023). Artificial intelligence in glaucoma: Opportunities, challenges, and future directions. BioMedical Engineering Online, 22(1), 51. https://doi.org/10.1186/s12938-023-01187-8