A review of methods in antimalarial sensitivity testing
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Abstract
In vitro assay is important tools to assess baseline sensitivity and monitor the drug response
of Plasmodium spp. Therefore the assays can provide background information for the development and evaluation of drug policies. The goal of this project was to conduct a systematic literature review using an online database to assess the current methods of antimalarial sensitivity testing.
Study selection: These studies reported the outcomes of methods in antimalarial sensitivity testing. Fives standardized protocols with predefined criteria were used to extract details on methods; parasitemia, incubation time. advantage and limitation.
Quality assessment: upon the review, participants were not blinded 100%. Blinding of assessor was totally unclear because of incomplete outcome data were addressed only 60%. In addition. The outcome data were 40% unclear. Four protocols were used to do meta analyze. The Forest plot showed that the malaria Syber green I-based fluorescence (MSF) assay is more effective than the HRP2 assay.
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