Study of the Relationship between the Sudden Death Due to Coronary Atherosclerosis and Homozygous and Heterozygous ABO Blood Group in Thai Population

การศึกษาความสัมพันธ์ระหว่างการเสียชีวิตกะทันหันเนื่องจากโรคหลอดเลือดแดงเลี้ยงหัวใจแข็งและตีบกับหมู่เลือด ABO ชนิดโฮโมไซกัสและเฮเทอโรไซกัสในกลุ่มประชากรไทย

Authors

  • Kanchana Sujirachato Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University, Bangkok
  • Piya Wongyanin Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University, Bangkok
  • Pramoon Arooncharus Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University, Bangkok
  • Vichan Peonim Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok
  • Jitta Udnoon Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok
  • Wisarn Worasuwannarak Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok

Keywords:

sudden death , forensic pathology , PCR, coronary atherosclerosis , ABO blood group

Abstract

          Coronary atherosclerosis is the leading cause of sudden death among Thai population, and the blood type may be associated with coronary atherosclerosis. In this study, ABO blood groups were analyzed in 231 deceased individuals aged 20-86 years by agglutination and modified PCR-SSP to determine the association of sudden death with coronary artery disease by autopsy and microscopic examination. Then the Odds Ratio (OR) was calculated. It was found that coronary atherosclerosis had a significant risk of sudden death with an OR = 3.125 (p < 0.0001, 95% CI = 1.821 – 5.362).  Blood group A and genotype AO were associated with sudden death with an OR of 2.071 (p = 0.028, 95% CI = 1.03 – 4.17) and 2.055 (p = 0.034, 95% CI = 1.00 – 4.22), respectively. There was no significant difference between B, AB and O blood types in sudden death and the incidence of atherosclerosis. However, it was found that people have blood type A (A and AO genotypes) with coronary atherosclerosis had a higher risk of sudden death than people with blood type A without coronary atherosclerosis with an OR = 2.526 (p = 0.087) and 3.224 (p = 0.053) in blood group A and AO genotypes, respectively. In conclusion, ABO blood group can be used for prediction of the chance of sudden death in people with coronary atherosclerosis.

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Published

31-07-2023

How to Cite

1.
Sujirachato K, Wongyanin P, Arooncharus P, Peonim V, Udnoon J, Worasuwannarak W. Study of the Relationship between the Sudden Death Due to Coronary Atherosclerosis and Homozygous and Heterozygous ABO Blood Group in Thai Population : การศึกษาความสัมพันธ์ระหว่างการเสียชีวิตกะทันหันเนื่องจากโรคหลอดเลือดแดงเลี้ยงหัวใจแข็งและตีบกับหมู่เลือด ABO ชนิดโฮโมไซกัสและเฮเทอโรไซกัสในกลุ่มประชากรไทย. AdvSciJ [Internet]. 2023 Jul. 31 [cited 2024 Jul. 27];23(2):R56-R73. Available from: https://li02.tci-thaijo.org/index.php/adscij/article/view/485

Issue

Vol. 23 No. 2 (2023): July - December 2023

Section

Research Articles

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