Study of the Relationship between the Sudden Death Due to Coronary Atherosclerosis and Homozygous and Heterozygous ABO Blood Group in Thai Population

การศึกษาความสัมพันธ์ระหว่างการเสียชีวิตกะทันหันเนื่องจากโรคหลอดเลือดแดงเลี้ยงหัวใจแข็งและตีบกับหมู่เลือด ABO ชนิดโฮโมไซกัสและเฮเทอโรไซกัสในกลุ่มประชากรไทย

Authors

  • Kanchana Sujirachato Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University
  • Piya Wongyanin Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University
  • Pramoon Arooncharus Department of Medical Technology, Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University
  • Vichan Peonim Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Jitta Udnoon Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Wisarn Worasuwannarak Division of Forensic Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University

Keywords:

sudden death , forensic pathology , PCR, coronary atherosclerosis , ABO blood group

Abstract

          Coronary atherosclerosis is the leading cause of sudden death among Thai population, and the blood type may be associated with coronary atherosclerosis. In this study, ABO blood groups were analyzed in 231 deceased individuals aged 20-86 years by agglutination and modified PCR-SSP to determine the association of sudden death with coronary artery disease by autopsy and microscopic examination. Then the Odds Ratio (OR) was calculated. It was found that coronary atherosclerosis had a significant risk of sudden death with an OR = 3.125 (p < 0.0001, 95% CI = 1.821 – 5.362).  Blood group A and genotype AO were associated with sudden death with an OR of 2.071 (p = 0.028, 95% CI = 1.03 – 4.17) and 2.055 (p = 0.034, 95% CI = 1.00 – 4.22), respectively. There was no significant difference between B, AB and O blood types in sudden death and the incidence of atherosclerosis. However, it was found that people have blood type A (A and AO genotypes) and with coronary atherosclerosis had a higher risk of sudden death than people with blood type A without coronary atherosclerosis with an OR = 2.526 (p = 0.087) and 3.224 (p = 0.053) in blood group A and AO genotypes, respectively. In conclusion, ABO blood group can be used for prediction of the chance of sudden death in people with coronary atherosclerosis.

References

Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basic of Disease. Saunders Elsevier, 9th ed. Saunders/Elsevier; 2015.

Udnoon J, Chirachariyavej T, Peonim V. Sudden unexpected deaths in different age groups at Ramathibodi hospital, Bangkok, Thailand : A retrospective autopsy study during 2003-2007. Southeast Asian J Trop Med Public Health 2009;40(1):162-8.

World Health Organization. Cardiovascular Diseases (CVDs) Factsheet. WHO Media. [Internet] 2021 [cited 2023 January 31] Available from http://www.who.int/new-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

รายงานประจำปี 2564 กองโรคไม่ติดต่อ กรมควบคุมโรค กระทรวงสาธารณสุข [อินเทอร์เน็ต]. 2565 [เข้าถึงเมื่อ 31 มกราคม 2566] เข้าถึงได้จาก: http://www. thaincd.com/

สถิติสาธารณสุข 2564 กองยุทธศาสตร์และแผนงาน กระทรวงสาธารณสุข [อินเทอร์เน็ต]. 2565 [เข้าถึงเมื่อ 31 มกราคม 2566] เข้าถึงได้จาก: http://bps. moph.go.th/new_bps/sites/default/files/statistic 64.pdf

Allan TM, Dawson AA. ABO blood groups and ischaemic heart disease in men. Br Heart J 1968;30:377-82.

Garrison RJ, Havlik RJ, Harris RB, Feinleib M, Kannel WB, Padgett SJ. ABO blood group and cardiovascular disease the Framingham study. Atherosclerosis 1976;25(2-3): 311-8.

Erikssen J, Thaulow E, Stormorken H, Brendemoen O, Hellem A. ABO blood groups and coronary heart disease (CHD). A study in subjects with severe and latent CHD. Thromb Haemost 1980;43:137-40.

Platt D, Muhlberg W, Kiehl L, Schmitt-Ruth R. ABO blood group system, age, risk factors and cardiac infarction. Arch Gerontol Geriatr 1985;4(3):241-9.

Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischaemic heart disease in British men. BMJ 1990;300:1679–82.

Tarjan Z, Tonelli M, Duba J, Zorandi A. Correlation between ABO and Rh blood groups, serum cholesterol and ischemic heart disease in patients undergoing coronarography. Orv Hetil 1995;136(15):767-9.

Wazirali H, Ashfaque RA, Herzig JW. Association of blood group A with increased risk of coronary heart disease in the Pakistani population. Pak J Physiol 2005;1:1-2.

Sheikh MK, Bahari MB, Yusoff NM, Knight A. Association of ABO blood group B with myocardial infarction. J Coll Physicians Surg Pakistan 2009; 19(8):514-7.

Lee HF, Lin YC, Lin CP, Wang CL, Chang CJ, Hsu LA. Association of blood group A with coronary artery disease in young adults in Taiwan. Intern Med 2012;51:1815-20.

Sujirachato K, Worasuwannarak W, Srisont S, Udnoon J, Peonim V. ABO blood group and coronary atherosclerosis in Thais at Ramathibodi Hospital. Siriraj Med J 2015;67(2):53-9.

Stakisaitis D, Maksvytis A, Benetis R, Viikmaa M. Coronary atherosclerosis and blood groups of ABO system in women. Medicina (Kaunas) 2002;38(Suppl 2):230–5.

Nydegger UE, Wuillemin WA, Julmy F, Meyer BJ, Carrel TP. Association of ABO histo-blood group B allele with myocardial infarction. Eur J Immunogenet 2003;30:201-6.

Garg P, Kumar J, Choudhary R, Chawla VK. Association between ABO blood groups and myocardial infarction in Jodhpur city of India. Bangladesh Soc Physiol 2012;7:13-7.

Biswas J, Islam MA, Rudra S, Haque MA, Bhuiyan ZR, Husain M, Mamun AA. Relationship between blood groups and coronary artery disease. Mymensingh Med J 2008;17(2Suppl):S22-7.

Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16(3):1215.

Lee JC, Tsai LC, Chen CH, Chang JG. ABO genotyping by mutagenically separated polymerase chain reaction. Forensic Sci International 1996; 82(3):227-32.

Fongsarun J, Nuchpryoon I, Yod-in S, Kupatawintu P, Kidprasirt C. Blood groups in Thai blood donors. Thai J Hematol Transf Med 2002;12:277-286.

Fornes P, Lecomte D, Nocolas G. Sudden out-of-hospital coronary death in patients with no previous cardiac history. An analysis of 221 patients studied at autopsy. J Forensic Sci 1993;38(5):1084-91.

Milroy CM. Coronary artery disease, sudden death and implications for forensic pathology practice. Diag Histopath 2017;23(11):479-85.

Additional Files

Published

31-07-2023

How to Cite

1.
Sujirachato K, Wongyanin P, Arooncharus P, Peonim V, Udnoon J, Worasuwannarak W. Study of the Relationship between the Sudden Death Due to Coronary Atherosclerosis and Homozygous and Heterozygous ABO Blood Group in Thai Population : การศึกษาความสัมพันธ์ระหว่างการเสียชีวิตกะทันหันเนื่องจากโรคหลอดเลือดแดงเลี้ยงหัวใจแข็งและตีบกับหมู่เลือด ABO ชนิดโฮโมไซกัสและเฮเทอโรไซกัสในกลุ่มประชากรไทย. AdvSciJ [Internet]. 2023 Jul. 31 [cited 2024 Apr. 18];23(2):R56-R73. Available from: https://li02.tci-thaijo.org/index.php/adscij/article/view/485

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Research Articles