Ethanolic extract of bran of red sticky rice (Oryza sativa L.) attenuates cellular oxidative stress in human hepatocellular carcinoma cell line (HuH-7 cells)
สารสกัดเอทานอลจากรำข้าวเหนียวแดง (Oryza sativa L.) ลดภาวะ oxidative stress ในเซลล์มะเร็งตับ HuH-7
Keywords:Red sticky rice bran extract, Oxidative stress, ROS, Glutathione
Oxidative stress is an imbalance event between free radical accumulation and antioxidant levels within the cells. It is the major cause of several chronic diseases. Red sticky rice is the pigmented rice, which being commonly cultivated and consumed in Thailand. Our previous study demonstrated that an extract from red sticky rice bran (RRBE) contains plenty of antioxidant substances. Thus, this research aimed to investigate the effect of RRBE against oxidative stress within the cells. The results showed that RRBE increased the cell survival rate of HuH-7 cells upon insulted with oxidative stress inducer, H2O2. Moreover, RRBE decreased the ROS production while increased glutathione production within the cells. Altogether, our results demonstrated the effect of RRBE against cellular oxidative stress proven its potential use as antioxidant supplement.
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